Research
The Heidelberg pH Capsule has been used in peer-reviewed research since 1960. More than 140 indexed publications span six decades, covering device validation, gastric acid physiology, pharmacokinetics, drug development, nutrient absorption, and clinical diagnostics.
The research spans institutions including the University of Heidelberg, the University of Michigan, UCSF, Thomas Jefferson University, and the University of Vienna, and includes pharmaceutical research by Pfizer, Merck, Genentech, GlaxoSmithKline, CIBA-Geigy, and Bristol Myers Squibb.
01
Dressman et al. 1990
Established reference gastric pH values still used in pharmaceutical modeling today.
02
Russell et al. 1993
Definitive elderly gastric pH dataset, dispelled the myth of universal age-related achlorhydria.
03
Mojaverian et al. 1985
Validated the capsule as a marker of gastric motility.
04
Yarbrough et al. 1969
Landmark US surgical validation establishing tubeless gastric analysis.
05
Yago et al. 2014
Demonstrated betaine HCl can rescue drug absorption in PPI-induced hypochlorhydria (Genentech/UCSF).
06
Liszt et al. 2017
Identified bitter-taste receptor mechanisms for gastric acid secretion (published in PNAS).
07
Ewe & Weis 1968
533-patient correlation between Heidelberg findings and gastric biopsy histology.
08
Surofchy et al. 2019
Most recent UCSF randomized controlled trial using the Heidelberg system.
The complete annotated bibliography with full citations and PubMed links is available on heidelbergmed.com.
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